Intestinal Ion Transport

Intestinal ion transport in NKCC1-deficient mice.

The Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl(-) entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. The basal short-circuit current did not differ between normal and NKCC1 -/- jejuna. In the -/- jejuna, the forskolin response (22 microA/cm(2); b...

Intestinal ion transport and the pathophysiology of diarrhea.

Identification of intestinal ion transport defects in microvillus inclusion disease.

Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results in secretory diarrhea, brush border (BB) defects, villus atrophy, and microvillus inclusions (MVIs) in enterocytes. How loss of Myo5b results in increased stool loss of chloride (Cl(-)) and sodium (Na(+)) is unknown. The present study used...

Intestinal ion transport: effect of norepinephrine, pilocarpine, and atropine.

The effects of parenteral pilocarpine, atropine, and norepinephrine on salt and water transport were studied in jejunum and ileum of anesthetized rats. Pilocarpine increased jejunal transmural PD, reduced absorption of Na, K, HCO3, and H2O, and increased secretion of Cl; in ileum, it caused secretion of Na and H2O, elicited secretion of K, and reduced the absorption of Cl. In both segments, per...

Ion transport across intestinal mucosa of winter flounder, Pseudopleuronectes americanus.

HUANG, K. C., AND THERESA S. T. CHEN. Ion transport acro.ss intestinal mucosa of winterjlounder, Pseudopleuronectes americanus. Am. J, Physiol. 220(6): 1734-1738. 197 1 .-Isolated winter flounder small intestine mounted in an Ussing chamber and bathed on both sides with teleost fish Ringer solution showed a PD ranging from 1 to 5 mv, with the serosa being electronegative to the mucosa. When the...